In recent times, there is an explosion of cosmetic procedures in the world. Nigerians have been going out of the country for these procedures. No study has been done to find out the likelihood of Nigerians to accept these developing procedures. The study is aimed at evaluating the factors that influence the acceptance of cosmetic procedures in South-South, Nigeria. A simple random sampling of 280 undergraduate students of the University of Calabar using questionnaires to evaluate the factors that influence the acceptance of cosmetic surgery in the region. The correspondents demographic data, the socio-cultural factors, economic status, personal self- rating of physical attractiveness, self esteem, personal experience with somebody who had undergone cosmetic surgery, cost and the willingness to undergo cosmetic surgery in the future were all assessed. A descriptive statistical analysis of data was used to evaluate the study. The respondents reported greater dissatisfaction with their body image, the influence of media, socio-cultural influence on physical appearance as the leading factors that influence the non clinical client population to undergo cosmetic procedures. Women reported greater likelihood of undergoing cosmetic surgery. Cost and religion did not have significant influence. The factors that influence the acceptance of cosmetic procedures among our people are multi-factorial. However, the dissatisfaction of the body image, socio-cultural factors, media and their personal experiences with people who had undergone cosmetic surgery was the motivating factors for the acceptance of cosmetic surgeries in the sub-region .It therefore, becomes necessary for the cosmetic surgeons in Nigeria to put in place suitable institutions to perform and improve on this practice.