The aim of the study is to determine the knowledge and practices of nurses towards postoperative pain management. The data collected from 92 participants were female nurses. In this study cross-sectional study design was used and self-administered structured questionnaire was conducted in government hospital Layyah Pakistan. Likert scale was used in this instrument. After data collection, it was analyzed by SPSS version 21. The results were analyzed in terms of descriptive statistics frequency, percentage for data analysis. A total of 100 questionnaire were returned from 120 questionnaires distributed to participant. Results of the study revealed that nurses have good knowledge about post –operative pain management but practices were not good Overall, study shows that knowledge of pain management of nurses statistically and significantly is good but practices were poor. In conclusion, patients are still hurting because of poor practices of nurses towards pain management thus the hospital management should focus on these factors to improve the nurse’s practices.