Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic disease, characterized by polyarthritis, erosive synovitis and sometimes shows multi system involvement. Oxidative damage induced by reactive species has been related to the pathophysiology of RA. The inflammation in the joints leads to joint damage and thus influences the quality of life in these patients. This work was undertaken to determine oxidative stress markers in patients with rheumatoid arthritis and to observe its correlation with inflammatory markers. Malondialdehyde (MAD) and Nitric oxide (NO) are estimated as the markers of oxidative stress and High sensitivity C-reactive protein (hsCRP) is measured as a marker of inflammation. A cross-sectional study in rheumatoid arthritis patients and healthy controls was done. We included 40 rheumatoid arthritis patients and 40 healthy controls. MDA, NO and hsCRP are measured in all the subjects. Statistical analyses were done using SPSS statistical software version 17.0. MDA, NO and hsCRP levels were increased in RA patients when compared to controls (p<0.001) and a positive correlation between the inflammatory marker and oxidative stress markers was also observed in these patients. The value of R is 0.7277 for MDA and hsCRP where as R value is 0.6153 for NO and hsCRP. The findings of present study support the concept of oxidative stress leading to tissue damage and inflammation. The positive correlation between inflammation and oxidative stress in these patients indicate the importance of correction of oxidative stress along with inflammation, further large and well controlled studies are needed to establish the role of anti oxidants in treatment protocols of RA patients.