A series of novel semicarbazone derivatives (BS1-22) of (2E)-2-[2-(1, 3-benzoxazol-2-ylsulfanyl)-1-phenylethylidene] hydrazinecarboxamide have been prepared. The structural conformation of the newly synthesized compounds has been established by elemental analysis, spectral analysis and melting point studies. Compounds BS1, BS3, BS9, BS10, BS11, and BS21 have been subjected to anticonvulsant screening by chemo-shock models. In the series, compounds BS9, BS10, and BS11 showed most potent result while compounds BS1, BS3, and BS21 were showing moderate results than standard drug.