Nasogastric tube feeding (NGT) is used for those patients who can-not sustain their oral requirements. Poor nursing adherence to evidence-based guidelines has negative consequences leading to higher mortality rates, delayed recovery and longer length of stay. Nurses play an intrinsic role in preventing these infections especially aspiration pneumonia by pursuing standard guidelines. Current study was designed to evaluate nurses’ knowledge and practices of NGT feeding in order to reduce complications. Cross-Sectional Descriptive Study design was proposed. Study population included 70 nurses working in three public sector hospitals in Lahore. Nurse’s knowledge was obtained using a self -structured questionnaire and their practices were recorded by direct observation through a checklist. Data was analyzed using SPSS 20. Data was represented in the forms of figures and tables. By knowledge and practice 60% secured under satisfactory level. Nasogastric tube feeding is a critical practice for seriously sick patients and errors in proper knowledge and skills can lead to serious complications. The present study could identify a high level of gaps in knowledge and skills of applying nasogastric tube feeding procedure. This necessitates the action at training institutions for nurses and on job protocols including monitoring for safety of patients.