Background: Numbness, tingling, discomfort, and/or weakness in the toes are symptoms of distal symmetrical polyneuropathy (DSP), which proceeds in a stocking-glove pattern proximally. There is still no particular therapy available. Objective: CPRF (caudal pulsed radiofrequency) is used to treat people who have sensory symptoms. Study Design: This is a prospective study at Alsdr teaching hospital in Iraq-Basra. Methods: CPRF, Boston Scientific G4™ RF Generator, Twenty-four subjects with DSP who were stimulated reported sensory complaints that did not respond to therapy. Under fluoroscopy at S2-3 level, inserted a caudal 21 gauge, 20-mm active tip RF cannula into the epidural space through the sacral hiatus. After the sensory and motor RF, give PRF at 5 Hz for 600 seconds at 45 V. Within the first week of the operation, the impact of activation was examined using a numeric rating scale, which was repeated every three months for the next three months. Patient satisfaction levels were assessed three months following treatment; patients who scored "7" (very good) or "6" (good) on the treatment satisfaction scale were rated fulfilled. Results: Neuropathic pain was effectively diminished after four visits (P< 0.001, test one-factor analysis). Furthermore, three months after receiving CPRF, more than half of the patients had an effective reaction (≥60 percent pain reduction) and were comfortable with the therapeutic outcomes. Limitations: The research included a small number of patients and was only for a brief time. Conclusion: CPRF is a safer, less expensive, and more effective way to treat symptoms.