Aim: This is a retrospective study which was carried out for a period of six months in orthopedic inpatient department at Aster prime hospital, Hyderabad. Objective: The objectives of the study are to decrease the irrational use of drugs to the patients, decrease unnecessary drugs, usage of proper dosage and administration of the drugs and prevent adverse drug reactions in order to improve the quality of life of patients. Methodology: A total of 104 prescriptions of the patient treated with analgesics and antibiotics for post-operative pain management were collected and analyzed in the inpatient orthopedic department. The prescriptions were analyzed and categorized into varieties based on antibiotics and analgesics prescribed, demographic parameters, comorbid conditions, type of orthopedic diseases diagnosed, polypharmacy etc. Conclusion: The study presented the prescription trends of antibiotics and analgesics in orthopaedic department. This kind of study will help as a guideline to use drugs for policymaking decision in the health care system. Prescribing medicines by generic names would help in less expensive treatment. Polypharmacy and combination of drugs has to be discouraged to minimize adverse drug reactions and drug interactions