Background: The major source of blood supply to long bones is by nutrient arteries in phases of ossification as well as during growth period Aim: to study the nutrient foramina of human femora and its surgical significance. Materials and Methods: 114 Dry femora (Right: 58, Left: 56) were collected from under graduate medical students and from the Department of Anatomy, Kurnool Medical College, Andhra Pradesh to study the morphometry of the nutrient foramina of human femora and its surgical significance. All the femur bones observed for number of nutrient foramen (NF) and location of nutrient foramen in the present study. The total length of each bone and distance of nutrient foramen from the proximal end of the bone was measured by using Osteometric board. Results: We noted 56 bones with single nutrient foramen on right femur bones, 2 bones noted with double nutrient foramen and also noted 55 bones with nutrient foramen on its linea aspera, 3 bones with nutrient foramen on its lateral surface out of 58 right femur bones in the present study. We noted 53 bones with single nutrient foramen on left femur bones, 3 bones noted with double nutrient foramen and also noted 52 bones with nutrient foramen on its linea aspera, 3 bones with nutrient foramen on its lateral surface, 1 bone with nutrient foramen on its medial surface out of 56 left femur bones in the present study. Conclusion: Variations in nutrient foramina is of great importance in understanding the blood supply of the femur bone for surgical procedures.