For many years medical community has attempted to standardize its approach to the assessment of patients. The vital signs are a valuable parameter with which to assess and monitor a patient's response to supportive treatment and antidote therapy. Vital signs play an important role in the practice of medical toxicology beyond evaluating and monitoring a patient's overall status as they are frequently valuable physiological clues to toxicology and disease gravity. In 1970’s two paediatric physicians Howard C Mortenson and Joseph Greensher, coined a term “Toxidromes” which is a combination word of toxic syndromes. They have quoted “Some common combination of manifestation which we have termed toxidromes can give a clue to the drug involved” in an article “The unknown Poison”. Aim: This paper aims to provide an understanding on the various vital signs and symptoms which is observed during poison treatment. Methodology: An extensive review of literature was carried out to elicit information on various vital signs and toxic syndromes. Results: The study revealed that the health care professionals on understanding various toxidromes can help them to identify the type of poison, its antidote and the can provide a better treatment. Conclusion: The healthcare professionals has to undergo training on toxidromes. Which can improve the treatment and outcome in any poisoning case