Antibiotics can enhance human lives by treating or preventing diseases. The prodigious, indiscriminate and improper use of antibiotics has played a substantial role in the outspread/emergence of antibiotic resistance bacteria. In the current scenario, a major public-health threat is the resistance to antibiotics. In addressing the problem on antibiotic resistance, the use of probiotics in lieu of antibiotics for treating certain diseases of host organisms has been investigated. Probiotics play a preventive role rather than a therapeutic role and is, thus, considered the opponents to antibiotics. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Most probiotics are common members of the human intestinal tract, and they are ingested in large amounts in functional foods. This review emphasizes on how antibiotics and probiotics face each other pertaining to antimicrobial resistance