Behçet’s disease is a systemic vasculitides, characterized clinically by recurrent mucocutaneous lesions but vital organs may by affected like central nervous which can increased the morbi-mortality especially among young patients. Infliximab, is a promising therapeutic approach for this disease especially in those with manifestations refractory to the standard immunosuppressive therapy. We report 3 cases of refractory neuro-Behçet’s disease with a dramatical clinical improvement under infleximab