Vernal conjunctivitis is a bilateral, recurrent inflammation of conjunctiva that tends to occur in children.The prominent features are itching, photophobia, redness, tearing, mild ptosis and thick ropy yellow mucoid discharge. The main clinical signs are cobblestone papillary hypertrophy, hyperemia of upper tarsal conjunctiva localized edema and Trantas dots. The three forms of vernal conjunctivitis are palpebral, limbal and mixed. Wide range of treatment modalities are now available for vernal keratoconjunctivitis.This study included 80 patients of both sex in the age group 5-25 years with any form and severity of vernal keratoconjunctivitis. Patients were randomly divided into two groups A and B. Group A patients were given cyclosporine (0.05%) eye drops and group B patients were given fluorometholone (0.1%) eye drops. The results were statistically analyzed by Mann Whitney Test and p value of <0.05 was taken as statistically significant. Maximum numbers of patients were below 15 years of age in both the groups and, in both groups; males were more than females.Most of the eyes presented with palpebral type of disease in both groups.Patients had maximum symptomatic relief at the end of fourth week in both the groups. Response to fluorometholone (0.1%) was significantly better than cyclosporine (0.05%)