Saudi Journal of Medical and Pharmaceutical Sciences (SJMPS)
Volume-5 | Issue-02 | 133-136
Original Research Article
An Experimental Study for Muscle Relaxant Property of Cuminum Cyminum in Albino Rat
Kamal Kishore Khichi, Akhtar Ali, Anusuya Gehlot, Rajkumar Rathore
Published : Feb. 28, 2019
Abstract
Aim: To evaluate muscle relaxant property of Cuminum Cyminum in albino rats. Methodology: This is an experimental study conducted at Department of Pharmacology, Dr. S. N. Medical College, Jodhpur (Rajasthan) on albino rats to find out the muscle relaxant property of Cuminum Cyminum standard drug was diazepam. Adult albino rats of either sex (100-150g) were divided into 3 groups. Group I consisting of 6 animals, served as control and received distilled water. Group II subdivided into three groups II-A, II-B, II-C, consisting of six animals each, received Cuminum cyminum in three doses of 300mg, 750 mg, 1000mg per orally respectively. Group III subdivided into three groups III-A, III-B, III-C, consisting of 6 animals each, received the standard drug in three doses per orally. Result: Cumin were tested as muscle relaxant and compared with diazepam as standard drug. P- value for fall-off time was not significant in all the three doses of Cuminum cyminum. Fall-off time was decreased by 0.70%, 0.91%, 2.40%, respectively with all the three doses of Cuminum cyminum. Conclusion: Skeletal muscle relaxant property of Cuminum cyminum aqueous solvent extract was not significant. It may be because extract got heat thermal degradation so it may be lost some of its property. According to some studies and animal models cumins alcohol solvent extract is having muscle relaxant property while it is having relaxant property for tracheal smooth muscle