A research was conducted to determine the anti-microbial susceptibility of some Escherichia coli isolates against common anti-microbial agents and Multi Drug Resistance (MDR) indices. The Escherichia coli isolates (n=51) obtained from cattle faeces and manure in abattoirs, cattle farms and livestock markets of Bauchi, Darazo and Katagum local governments of Bauchi state, Nigeria were screened for anti-microbial susceptibility against 12 common anti-microbial agents. The susceptibility test was carried on all the 51 isolates to determine their antibiotic resistant profiles using the disc diffusion method developed by Kirby – Bauer and standardized by the World Health organization (WHO), commercially available antimicrobial disks impregnated with the different antibiotics were then tested. The results revealed highest resistances of the isolates to Cephazolin (86.2%), followed by Sulfamethoxazole (82.4%) and Enrofloxacin (78.4%). The research also revealed that the highest level of susceptibility of the isolates to the antimicrobial agents was found against chloramphenicol (78.4%), followed by gentamycin and Imipenem with (68.6%) and Ceftriaxone (58.8%) respectively, the results further indicated 50(98%) of the isolates resistance to 3 or more of the antibiotics. All isolates showed Multi-drug resistance pattern (MDR), some among the isolates showed resistance against up to 8 antimicrobial agents belonging to 7 different groups of the antimicrobial agents. The MDR indices of E. coli strains indicated resistance against the antimicrobial agents at various levels of antibiotic groups