The duodenal diverticulum is a hernia of the duodenal wall. Its frequency varies from 2 to 20%. The symptomatic forms are rare but particularly serious because often revealed by a complication. The discovery is most often fortuitously on the occasion of a Cholangio Endoscopic Retrograde Pancreatography. The purpose of our work is to study the clinical endoscopic and therapeutic epidemiological aspects of duodenal diverticula. Materials and methods: This is a retrospective descriptive study conducted in the department of diseases of the digestive system "Medicine C" at Ibn Sina Hospital in Rabat. We collected all patients with duodenal diverticulum over a 12-year period (November 2005 to June 2016). Patient data were exploited from the Cholangio Endoscopic Retrograde Pancreatography (ERCP) registers. Results: Between November 2005 and June 2016, 664 ERCP were performed, 41 duodenal diverticula were observed; that is 6.2%. The average age of our patients was 68.6 years with extremes ranging from 38 to 85 years; 58.5% of the subjects were over 70 years of age with a clear predominance of women (34 women, 7 men) and one sex ratio F / H = 5. Clinical symptomatology was caused by cholestatic jaundice, cholangitis, acute pancreatitis. A liver test predominantly exhibited cytolysis associated with cholestasis. All our patients benefited from a radiological assessment including abdominal ultrasonography, CT, bili-MRI, echoendoscopy and Kehr drain cholongiography; the diagnosis of a lithiasis of the bile duct was raised in 80% of cases. ERCP performed in all our patients has a fortuitous discovery of duodenal diverticula. The characteristics of these diverticula were revealed by ERCP: a single diverticulum was observed in most cases (36 patients or 88%), two diverticula in 4 patients (10%) and three diverticula in one patient (2%). All the diverticula were juxta-papillary (at the level of D2). The papilla was paradivecticular in the majority of cases (30 patients, 73%), intradiverticular in 7 patients (17%) and interdiverticular in 4 patients (10%). The presence of duodenal diverticula had an impact on the feasibility of ERCP: catheterization of the papilla was difficult in 6 patients (14%) but managed in 8 patients (19%), 5 patients had paradiverticular papillary, 2 interdiverticular and one intradiverticular. Endoscopic treatment of bilio-pancreatic pathology associated with duodenal diverticula was performed in 23 patients: 16 patients underwent computed extraction of the hand bile duct. Seven patients were referred to surgery. Conclusion: The duodenal diverticulum is the second most common site of digestive diverticula after the colon. The absence of specific signs makes the positive diagnosis difficult.