Background: Adequate knowledge empowers healthcare providers to succeed in their roles as promoters of public health. However, it has been reported that even healthcare workers are not exempted from having poor knowledge of epilepsy. Identification of such gaps in knowledge, albeit at an early stage, is beneficial. Objectives: To assess epilepsy knowledge among final year medical students in Calabar, Nigeria, in order to identify existing knowledge gap and generate data to guide design of training modules, on epilepsy, for healthcare professionals. Methods: With the use of convenience sampling method, we conducted a survey on epilepsy knowledge, among final year medical students of the University of Calabar, using a structured questionnaire incorporating the epilepsy knowledge scale. Data analysis was done with version 20 of the SPSS statistical package. Results: Seventy nine medical students, with 4 to 8 years duration of medical training, participated in the study. 2.5%, 19.0%, 51.9%, 25.3% and 1.3% of them had very poor, poor, borderline, good and very good levels of epilepsy knowledge, respectively. Conclusion: The respondents had poor knowledge of epilepsy, which could impact the quality of epilepsy care in the region. The identified gaps should be considered while designing training modules for healthcare professionals