Aim: The aim of the study was to evaluate the hemodynamic effects of radio-contrast media i.e Iohexol and Diatrizoate Sodium in patients visiting the Radiology department for CT scan. Methodology: It was an observational study, conducted at Mahatma Gandhi Hospital Jodhpur (Rajasthan). Pulse rate and blood pressure were measured three to five times, before administration of Iohexol or Diatrizoate Sodium, after 5 min and 1 hr after administration of Iohexol and after 1 hr and 2 hr starting of administration of Diatrizoate Sodium. Results: 5 minutes post-Iohexol administration increased in SBP was observed in 66.66% and decreased SBP observed in 21% participants. While 58.66% participant’s DBP decreased and 37.33% participant’s DBP increased. 1 hr post-Iohexol administration in 44% individuals recorded fall in SBP and in 56% individuals recorded rise in SBP compare to the pre-Iohexol administration. 1-hour post-Iohexol administration, in 60% participants recorded decreased DBP and in 32% participant recorded rise in DBP. In 65.33% cases, PR increased within 5 minutes after Iohexol administration while 81.33% participant’s PR was increased, 1 hr post-Iohexol administration. After 1 hr starting of Diatrizoate Sodium administration, decrease in SBP was recorded in 38.46% and increased in SBP recorded in 46.15% participants while incidence of decreased in DBP was in 38.46% cases and increased DBP was observed in 23.07% cases. 2 hr post Diatrizoate Sodium administration in 57.69% participants increased in PR observed. Conclusion: Post Iohexol administration SBP and PR were increased but DBP decreased. But these were clinically insignificant fall or rise in BP or PR except increased in PR 1 hr post-Iohexol compare to pre-Iohexol which was clinically highly significant. Post-Diatrizoate Sodium administration SBP and DBP were decreased whereas PR was increased compared to pre-Diatrizoate Sodium but this fall in BP and rise in PR is clinically insignificant