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Saudi Journal of Medical and Pharmaceutical Sciences (SJMPS)
Volume-5 | Issue-08 | 718-723
Original Research Article
Development and Evaluation of Mouth Dissolving Tablet of Taste Masked Naratriptan HCL using Sublimation Technique
Shoaeb Mohammad Syed, R P Marathe, P R Mahaparale, S R Shahi
Published : Aug. 21, 2019
DOI : 10.36348/sjmps.2019.v05i08.004
Abstract
The aim of current study was to develop simple and convenient dosage form for delivery of naratriptan hydrochloride. Mouth dissolving tablets of Naratriptan HCl were prepared using superdisintegrants Croscarmellose sodium, sodium starch glycolate, crospovidone, using sublimation methods. Camphor was used as a sublimating agent. The prepared tablets were evaluated for thickness, uniformity of weight, content uniformity, hardness, friability, wetting time, water absorption ratio, in vitro disintegration time and in vitro drug release. The tablet disintegrate in vitro within 12-14 sec. Almost 95% of drug were released from all formulations within 10 min. The formulations containing camphor, crospovidone was found to give the best results. The tablets prepared by this method exhibited higher rate of release
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