Chemotherapy induced peripheral neuropathy is a disabling pain condition resulting from cancer therapy. However, no scientific data available for many herbal drugs which are locally used and evaluating these drugs would be worth to have scientific approach of using them. In this study an indigenous plant called Clerodendrum viscosum leaves have been used to evaluate the effect of plant in vincristine induced peripheral neuropathy in rat model. Vincristine sulfate was administered to Male sprague dawley rats to induce neuropathy. Pain behavior was assessed by Hot plate, Cold plate, sciatic function index and formalin test were also estimated. Animals were sacrificed and the sciatic nerve excised for histopathological studies. The whole preclinical studies revealed that the aforementioned plant extract exhibited less neuronal damage. The study concluded that methanolic extract of Cleodendrum Viscosum leaves can used against chemotherapy induced peripheral neuropathy.