The positive diagnosis of autoimmune pancreatitis (AIP) can be challenging and poses a problem of differential diagnosis with pancreatic cancer. It’s most sensitive and specific biological marker is the serum IgG4 level. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) plays a key role in the positive and differential diagnosis. Treatment is based on corticosteroid therapy. We report the case of a 43-year-old female patient admitted for cholestatic jaundice with a cephalic pancreatic mass on imaging simulating pancreatic cancer.