Aminoglycosides antibiotics have been in use for a long time. They are bactericidal in nature and are used to treat infections by Gram-negative bacteria. Studies have revealed their dangerous effect on human body that is the Ototoxicity. Aminoglycosides-induced ototoxicity has resulted in permanent hearing loss. Different agents are being examined for their activity against aminoglycosides-induced ototoxicity. These agents govern mostly on the principle of antioxidant capacity