This study was carried out to investigate the prevalence profile of cutaneous adverse drug reactions (CADRs) on in patients at Tongji hospital. A retrospective study was carried out on in-patients at Tongji medical college, Huazhong university of Science and Technology from May 1985 to April 2012. Out of 110553 in-patients 777 cases were diagnosed as CADRs. The most common type of CADRs was maculopapular eruption followed by Erythema multiforme, Fixed drug eruption and urticaria. The most common drugs causing CADRs was antibiotics followed by antiepileptic drugs, antipyretics and analgesics. The most common type of CADRs was maculopapular eruptions followed by erythema multiforme, fixed drug eruption and urticaria. The main offending drug was antibiotics followed by antiepileptic drugs, antipyretics and analgesics