The present study aimed at the In Vitro Evaluation of Xanthine Oxidase Inhibitory Activity of Apium graveolens dulce and Bryophyllum pinnatum kurz. The activity was performed usingethanolic extract of leaves and stalk of Apium graveolens dulce and fresh juice of leaves of Bryophyllum pinnatum kurz at various concentrations (100µg, 200µg, 300µg, 400µg, 500µg, 600µg, 700 µg, 800µg). In this study Allopurinol was used as a standard drug. The results were noted in terms of highest percentage inhibition of Xanthine oxidase. The combination of ethanolic extract of leaves and stalk of Apium graveolens dulce and fresh juiceof leaves of Bryophyllum pinnatum kurz shows significant effect at highest concentration such as 800µg in combination group