Safe administration of parenteral medication is very important for the quality care of patient and it is very important for the cure of disease and promoting client health. Every individual nurse should know about the importance of safe administration of parenteral medication and should have enough knowledge to perform safe practice. To assess the knowledge of nurses regarding safe administration of medication. A cross sectional descriptive study design was used in this research project for assessing the knowledge of nurses about safe administration of parenteral medication, the sample size was 200 nurses which are selected from Punjab institute of cardiology randomly and the data was collected from the participants through self-administered questionnaire. It is reveled from the study that 99.5% of the participants was female while only 0.5% are male, 47% of the participants were belong to age group 35-45 years of age and 56% of the nurses were strongly agree to the safe administration of parenteral medication. Study participants have enough knowledge regarding the safe administration of parenteral medicine