Alopecia actuated by chemotherapy is a much-feared unfavorable impact by numerous ‎chemotherapy protocols. Alopecia induced by chemotherapy is considered the most mental stunning highlights of ‎cancer treatment. A few medicines have been researched as conceivable approaches to anticipate hair ‎loss, however, none has ‎been effective. To date, still no accomplishable approach or treatment for overcoming chemotherapy-‎induced alopecia. Utilizing developed new sub-atomic innovation, spots and featuring in understanding sub-atomic systems of chemotherapy-prompted alopecia has been ‎accomplished utilizing rat models. Numerous systems can clarify the pathobiology of the ‎response of human hair follicle to chemotherapy albeit some to a great extent stays obscure. ‎In this article, we audit pathobiology of chemotherapy-initiated alopecia ‎, we concentrate on the ‎roles of p53, CDK2 and its objective qualities that are vital in interceding reactions of hair ‎follicle cells. ‎We expect that nearby pharmacological hindrance of p53 and CDK2 activity may fill in as an ‎effective treatment to avert chemotherapy-incited balding. Adequate pharmacological ‎inhibition of chemotherapy-induced male pattern baldness may require a blend of inhibitors to ‎block correlative or excess pathways of apoptosis in hair follicles. Estimation ‎chemotherapy instigated alopecia is vital and the related subject we open to it in this ‎review. Moreover, in this review, we will clarify the biomolecular link between the degeneration of ‎hair follicle induced by chemotherapy and the mechanism of propranolol in controlling P53 and CDK2 as protection ‎from alopecia induce by chemotherapy