This study seeks to investigate the effects of chronic consumption of fresh palm oil (FPO) and thermoxidized palm oil (TPO) diets on indices of haemostasis and related organs. Eighteen male rabbits weighing 750–1000g were randomly divided into 3 groups (n=6), namely; Control, FPO fed group and TPO fed group. The control group received normal feed+water, FPO fed group received normal feed mixed with FPO in the ratio 85:15g respectively, while TPO received normal feed and TPO in the ratio 85:15g respectively. The feeding lasted for 6months, after which indices of haemostasis were assessed. Platelet count for TPO group was significantly lower compared with control (p<0.05) and FPO group (p<0.001). Bleeding time in the TPO group was significantly higher (p<0.05, p<0.001) when compared with control and FPO respectively. Clotting time for TPO group was significantly higher (p<0.01) compared with control, but significantly lower (p<0.05) in FPO group compared with control. Prothrombin time for TPO group was significantly higher (p<0.001) compared with FPO group, whereas PT was significantly lower (p<0.05) in FPO group compared with control. Photomicrograph of the liver in the TPO group showed extensive diffuse steatosis and progressive inflammation with hepatocellular necrosis, while the bone marrow in TPO group showed infiltration with adipose tissue and reduction in the number of blood forming cells. Chronic consumption of thermally oxidized palm oil predisposes to thrombocytopenia secondary to infiltration of the bone marrow with adipose tissue and reduction in the number of blood forming cells. It also increases bleeding time, clotting time and prothrombin time and hence may predispose to prolonged haemorrhage.