Effective care can reduce almost 3 of the 4 million deaths of babies under-one month. Essential newborn care should be applied immediately after the baby is born and continued for at least the first 7 days after birth. Study was aimed to assess the knowledge and practice on essential newborn care among primipara mothers. A hospital based cross sectional was conducted with 60 samples who met the inclusion criteria by using convenient sampling technique. Structured questionnaire and check list was used to collect the data and data were analyzed by descriptive and inferential statistics. The present study observed that out 60 samples, 16(26. 7%) had inadequate knowledge, 30(50%) of them had moderately adequate knowledge and 14(23.3%) of them had adequate knowledge. Regarding practice 16(26. 7%) of them had poor practice, 28(46. 7%) had good practice and eight (26. 6%) had best practice. There is a positive correlation between the level of knowledge and level of practice on essential newborn care among primipara mothers and but not statistically significant. Health care professionals are actively participating in providing health education to the antenatal mother regarding essential newborn care and creating environmental conditions for better hygiene and reduced exposure to contamination makes children less susceptible to diseases and infections that may lead to death there by can improve health status of the newborn and reduced the newborn mortality rate.