In the present work, two simple and sensitive UV spectrophotometric methods have been developed for the quantitative estimation of Metformin Hydrochloride and Benfotiamine in combination using bulk and pharmaceutical dosage forms. Method A is Simultaneous equation method which involves measurement of absorbance at selected wavelength and solving the simultaneous equation to calculate the amount of drug present. Distilled water was used as the solvent for the analysis of both drugs. Two wavelengths 230 and 246 nm were selected for the estimation of Metformin Hydrochloride and Benfotiamine. LOD for Metformin Hydrochloride and Benfotiamine were found to be 0.03µg/ml and 0.27µg/ml respectively. Method validation was done as per ICH guidelines. Method B is Absorbance ratio method which involves, formation of Q-Absorbance equation at 239 nm (isoabsorptive point) and 246 nm (λmax of Benfotiamine) in distilled water. The Linearity lies between 2-16 µg/ml for Metformin Hydrochloride and 2-18 µg/ml for Benfotiamine with r2=0.999 and 0.998 respectively. LOD for both drugs were found to be 0.16 µg/ml and 0.3 µg/ml respectively. Method validation was done as per ICH guidelines