Tumors of the central nervous system represent a heterogeneous group of tumors with a varied histopathologic spectrum and a variable frequency. In this study, we retrospectively analysed the epidemiological and the histopathological data of central nervous system tumors collected in our department. This study includes 657 central nervous system tumors histologically diagnosed from 2004 to 2016. It concerns all CNS tumors according to the WHO classification. The characteristics of patients, including age, sex, location, and histologic diagnosis were analyzed. Tumors were equally seen in males and females (sex-ratio=0.99:1). The mean age at the time of diagnosis was 38 years. 24% were children and teenagers. The commonest location was intracranial (92.3%). The primary tumors accounted for 92.8% of CNS tumors. Tumors were benign in 53.5% and malignant in 46.5% of cases. The most common histologic type is astrocytic tumors (30%), followed by meningeal tumors (26.7%). In adults, the three commonest categories were meningothelial tumors, astrocytic tumors and oligodendroglial tumors. For children and teenagers, astrocytic tumors were the most prevalent, followed by embryonal tumors and ependymal tumors. There was a male predominance for astrocytic, ependymal and oligodendroglial tumors and medulloblastomas. In contrast, meningiomas and schwannomas were more frequent in female. The most frequent intracranial tumors were astrocytic tumors, meningeal tumors and embryonal tumors. In spinal cord, meningeal tumors, schwannoma and ependymal tumors were the most prevalent. In the absence of a national register of CNS tumors in Morocco, we performed this study which may reflect epidemiological and histopathological characteristics of these tumors in our region. Globally, our results were in accordance with those of other studies around the world. However, we noted a higher proportion of tumors in children and teenagers