The roots of Ipomea involucrate (IP) and Rauvolfia vomitoria (RV) and the leaves of Milletia aboensis (MA) are reportedly used for the treatment of mental illness. This study investigated the anticonvulsant potentials of these plants. Ethanolic crude extracts of IP and RV (50, 100, and 200 mg/kg bw, ip) and MA (100, 200, and 400 mg/kg bw, ip) were administered to respective groups of mice (n=6). The positive control group received 30mg/kg bw, ip of Carbamazepine, while negative control group received 1% DMSO (vehicle). After 30 min, epilepsy was induced by injection of 4-Aminopyrydine (4-AP) (15mg/kg bw ip). They were observed for the next 30min. The ability of the extracts to delay the onset of trembling, hindlimb extension, seizure, and protect from death as compared to the untreated group was taken as a sign of anticonvulsant activity. Ethanolic crude extracts of MA, RV and IP possess anticonvulsant potencies in the order -MA>RV>IP; with MA protecting two-thirds of animals against death from 4-AP-induced seizures. The plant extracts have the potentials of tackling generalized tonic-clonic and partial seizures. MA and RV may exert their effects by acting on ion channels while IP is most likely to act via other mechanisms