The rate of non-fatal deliberate self-harm (DSH) in Sri Lanka has increased in recent years, with associated morbidity and economic cost to the country. Pesticide ingestion is the commonest mode of suicide in Asia with an estimated loss of around 300,000 lives every year. We conducted a cross-sectional observational study in patients with 12 years of age and above who were admitted with deliberate self-harm (DSH) in Teaching Hospital Batticaloa, SriLanka. Of the 121 patients observed 83 (68.6%) females and 38 (31.4%) males. Among them, 119 (98.34%) cases (1.65%)) were of intentional poisoning and only two cases (1.44%) were of accidental poisoning. In this study, the majority of victims 47(38.84%) were young age group (20-29). Forty-two (34.71%) were teenagers.In the present study, the commonest poisoning agent was yellow oleander seeds 33 (27.3 %) followed by organophosphorus compounds 23(19%) and Paracetamol overdose 22 (18.2%). These findings support a strategy of limiting easy access to pesticides and oleander, and for improving the supply and effectiveness of antidotes, as a strategy for reducing fatal self- poisoning in rural SriLanka