Acute myeloid leukemia (AML) is a very heterogeneous group of hematological malignancies, Characterized by clonal proliferation of abnormal myeloid precursors and altered normal hematopoiesis. The world Health organization (WHO) classification retains the diagnostic threshold the infiltration of the bone marrow by more than 20% of non-lymphoid blasts. AML 2 represents 30% to 40% of AML, the translocation (8; 21) is identified in 5% to 10% of all AML cases and 10% to 22% of AML2 cases. We report a case of AML 2 discovered in a 56-year-old woman, during a paraclinical assessment of acute pancreatitis. The hemogram showed a pancytopenia. The blood smear revealed the presence of circulating blasts estimated at 36%. The medullogram revealed a medullary invasion by undifferentiated blast cells estimated at 59%, Myeloperoxidase staining was positive. The patient was given antibiotic therapy and rehydration. An extra-renal treatment was performed due to the installation of acute renal failure. Evolution was marked by death following infectious complications