The Present study was carried out to analyse the prescribing pattern of drugs and appropriateness of antimicrobials use in gastroenteritis in hospitalized children. It was a prospective, observational, single centre study undertaken in gastroenteritis inpatients of paediatric department, aged one month to seventeen years, over a period of six months. Modified Kunin's criteria along with the guidelines set by the World Gastroenterology Organization were followed for assessing the appropriateness of the antimicrobials prescribed and prescribing patterns respectively. A total of 120 patients were enrolled, of whom 61% were in the age group below 5 years. Diarrhoea with mild dehydration was diagnosed in 53% patients followed by no dehydration (28%) and severe dehydration (19%). IV fluids (90.8%) and antimicrobials (86.6%) were the commonest drugs prescribed. 89% of antimicrobials were given in parenteral dosage form. 27.9% of antimicrobials were given for 3 days duration. Among the antimicrobials, ceftriaxone was frequently prescribed. Inappropriate antimicrobial therapy was given in 9.6% of the cases. Precise use of antimicrobials was preferred in 10.5% of cases. Microbiology report was missing in 79.9% of cases. No ADRs were observed during the study. Inappropriate use of antimicrobials was seen in the study. Emphasis on proper diagnosis, treatment, education and availability of effective guidelines may help in a judicious use of drugs in children.