It is very vital for this profession to provide Nursing care and treatment with great quality and respond to client’s requirements. Leadership styles has a great role in professional task achievement, in this study was investigated the relationship between leadership styles (Transformational & transactional leadership style) work related stress in registered staff nurses. The aim of the study was to assess the impact of leadership styles for reducing work related stress among nurses. Quantitative descriptive cross sectional study design was used. Demographic information was presented such as age, sex, education, experience etc. In second part, transactional, transformational leadership style and work load questions are analyzed on the basis of 5 point Likert scale (1= strongly agree 2= Disagree 3= Neutral 4= Agree 5= strongly agree). Simple convenient sampling technique was used and Sample size was 180 Nurses from selected hospital. Reliability was checked on Cronbach, s alpha, it was .925 for Work Load, .969 for Transformational Leadership Style and .803 for Transactional Leadership Style that is reliable. Data was analyzed through SPSS software 21, and results shows that transformational leadership style has significant negative correlation with workload (r = -.673, p =0.00). While transactional has significant positive relation with work load (r =.493, p =.000). Transformational leadership style has negative relationship with work load. While transactional has positive relation with work load