Post-dengue fatigue syndrome (PDFS) is not uncommon phenomenon of dengue viral infection. The PDFS has wide spectrum of musculo-skeletal and neurological features. It was observed in 25% of hospitalized patients with dengue. The exact pathogenesis is not known, but this complex interaction of immune, endocrine, musculoskeletal and neurological system act through the hypothalamic-pituitary-adrenal axis causing clinical features of fatigue in dengue. Persuade a balanced diet, and converse with patients their nutritional habits. Advice about graded exercise is essential. Anti-depressants are of minimal benefits for post viral fatigue. I performed systematic reviews of the published literature. The database, Pubmed was searched using the term of ‘dengue fatigue’ or ‘Post dengue fatigue’, or ‘post viral fatigue’ and ‘post infectious fatigue’ in any field with no data limits. After exclusion of double entries, I assessed all publications. I included articles related to fatigue due to post viral and dengue viral infection. Two articles were found related to post dengue fatigue syndrome. The rest of the information was extracted from the articles related to post viral fatigue syndrome