Ocular drug delivery is challenging field to pharmaceutical scientists owing to the underlying anatomical, physiological and dynamic constraints put forth by the eye. Nonetheless, there is increasing need to overcome these barriers for the treatment of sight threatening ophthalmic ailments. Novel drug delivery strategies are being explored while intravitreal injections are still a standard treatment for the efficient treatment of ocular disorders. Topical ophthalmic in situ gels could be viable platform to increase mucoadhesivity, pre-corneal residence and thereby ocular bioavailability of drugs. In this review, various topical in situ gel formulations exploited for ocular delivery are summarized.