Cryptococcal infection is characteristically associated with immunocompromised status. In most cases, the skin lesions represent a sentinel finding for disseminated cryptococcal infection. We describe a case of a 34 year old male, a solid organ transplant recipient (SOT), on immunosuppression, presenting with necrotising fasciitis of right lower limb. On microbiological and histopathological examination, a diagnosis of disseminated cryptococcal infection was made. In this report, we describe the spectrum of disease associated with Cryptococcus, its life cycle, pathogenesis and Immune Reconstitution Inflammatory Syndrome (IRIS). Cryptococcosis is a serious infection among SOT recipients, with diverse clinical features. This report underscores the need for a multidisciplinary clinical research and education from the Indian perspective.