Nurses provide care to patients and they feel hope to get comfort and recover. Nurses use the knowledge and skills to provide care to the patients. There are many health care professionals who involved in providing care for sick patients but nurses are the central part of this process. There are many tasks which nurses have to perform in routine and medication administration is one of them. To assess nurses’ perception about medication administration errors and the factors that are associated with the medication packaging, physician communication, pharmacy process, nursing staff and medication administration. Descriptive cross sectional study design and quantitative survey technique was used in this study. The sample size of this study was 264. The self-administered questionnaire was distributed to 300 nurses of Children Hospital, Lahore, Pakistan through convenient sampling and all the participants were females. The study found that nursing related factor is the highest reason of the medication error among the nurses of the Children hospital Lahore, Pakistan. However, pharmacy is the lowest reason of the medication error. Thus, management should focus on the training and development of the nurses regarding medication error so that the better health care services can be ensured