Body mechanic means the use of body as a machine and as a mean of movements efficiently. It should be practiced in every moment of life. People from all profession are almost affected with back pain and other musculoskeletal problems. Nurses experience low back pain more than other group, incidence varies among countries. Nurses need to use body mechanic technique during performing every procedure. They can use body mechanics more effectively if they have well knowledge about it. Purpose of this study was to assess the knowledge and practices of body mechanic techniques. A cross sectional descriptive design was used for this study. A sample of 216 nurses was taken by using convenient sample technique. Instrument used for this study was set of questioner compose of demographic data, nurse’s knowledge and practices of body mechanic technique. Scoring was based on likers scale. Data was analyzed on SPSS (version 21) and results were presented in tables, pie charts and table for the demographic data, bar charts and table was used for the knowledge and practices of the participants. The demographic data revealed that all of the nurses were female and 41.3% (n=93) belong to the age group of 26-30years. Majority were from the ICU/CCU and having job experience of 0-5 years. 173% (n=173) were having diploma of general nursing and midwife as a qualification. 65% of nurses had fair knowledge about the body mechanic technique and 35% with poor knowledge. In term of practices, 60% nurses were practicing body mechanic techniques while the rest of 40% were not practicing. However, back pain is prevalent problem among nurses. Majority of the nurses was having knowledge about body mechanic technique but less was practicing it. Nurses need to be more educated about body mechanic technique and they should be emphasized to practice it in performing nursing procedure as well as in routine life