Job dissatisfaction can cause the nurse’s burnout. The job at the hospitals produces the severe mental exhaustion or burnout. The purpose of the study is to examine the relationship between job satisfaction and nurse’s burnout among the registered nurses at Jinnah hospital Lahore, Pakistan. The descriptive correlational study design was utilized. The questionnaire was distributed to 260 registered nurses at Jinnah hospital included in the study, and head nurses midwives, assistance nurses were excluded from the study. Data was collected through convenient sampling technique and data was analyzed by using SPSS version 21. The results of the study depict that job satisfaction has significant negative relationship with nurses’ burnout. Therefore, hospital’s administration should emphasize on the factors which keep the nurses satisfied and the burnout of the nurses can be avoided. The study provides the limitations and recommendation in the end