Patient satisfaction is an integral part of the quality care in health care setting and also a very important factor to measure the quality nursing care. Satisfaction is a fundamental concept that depends upon various factors such as patients' past experience with the nursing care, their future expectation from nurses and social, ethical and moral values of the individuals. Hospital organization directly depends upon their patients; more patients were come when they were treat with the best quality of care. Now a day’s nurses are responsible for providing quality of care to patients but unfortunately they are not satisfied with their jobs due to following factors like: stress, workload, and unsafe working environment. This increases mortality and co morbidity rate and serious adverse events in the world. Quantitative descriptive correlational design was use in this study. The main aim of descriptive correlational study is to check the association between nurse’s job satisfaction and quality of care and factors which affecting on quality of care. Data analyzed by SPSS version 21.Sample size was 222 by convenience sample technique, 5 point scale likert scale questionnaire was used. Data collected by Register Nurses of Jinnah hospital Lahore, Pakistan. This study found that nurses’ job satisfaction and quality of care are positively correlated. 68.5% of participants believed the quality of care they provided was affected by employee job satisfaction. The finding of this study concluded that there was a positive correlation relationship between nurses’ job satisfaction and quality of care they deliver. This study also proves that work load, stress and unsafe work environment were main factors which effect on quality of care