Pulsatile Drug Delivery System are the system where in there is a rapid and transient release of an active molecule within a short time period produced immediately after a predetermined off release period. In this present study efforts are made to formulate and evaluate chronotherapeutical drug delivery system of Losartan and Hydrochlorothiazide in the form of bi layered tablets for the treatment of hypertension by using various synthetic polymers. The compatibility study between drug and polymer was done by FTIR. Blend analysis of Losartan and Hydrochlorothiazide layers were studied. Based on the results these were formulated into bi layered tablets. Various evaluation tests of the tablets like weight variation, disintegration test and friability test etc were carried out. In vitro drug releases of the formulated tablets were carried out. Results of these studies indicated that the formulated bi layered tablets achieved a burst release after 3h-4 h lag time and hence can be used as the pulsatile drug delivery for hypertension. From this present work it can be concluded that pulsatile release of drug in the form of bi layered tablet can be achieved for newer chronotherapeutical drug delivery system