Drug related adverse effects may be minor or major. Pharmacists have an ethical obligation to notify the appropriate bodies whenever adverse effects where suspected. Stroke affect one’s physical and communication abilities, as well as causing emotional changes and difference in behaviour. The study underlines the importance of monitoring stoke survivors emotional and behaviour alternation. The objective is to determine the drug utilization review in post stroke patients and to assess the adverse reactions in stroke management. Cross-sectional prospective study was performed for six-month and the patients diagnosed as stroke and wished to participate were identified. All the subjects were evaluated for adverse drug reactions through telephonic or face to face interview. Out of 52 patients 71.15% were males and 28.84% females. The mean age of the patients was 63.21 (±10.19) years and 61% patients had Blood Pressure, followed by 55% Dyslipidymia, 42% Diabetes Mellitus. A total of 38 incidences of ADRs were observed during the study period for 15 patients. The highest reported ADR was GI bleeding (17.3%) followed by GI Distress and Constipation. Causality of ADRs found to have probable 74%, possible 23.6% and definite 2.6% and no doubtful categories. The study results cleared that majority of the stroke patients have adequately severe neurological impairment and need assistance to carryout activities of daily living. Majority of the patients seems to have mistaken the symptoms of ADR to be due to the disease being treated and old age. Drug utilisation studies should be carried out in large number of population and at different locations which helps to reduce the drug related problems and improve the rational use of drugs by the patients.