Type 2 diabetes mellitus is associated with increased metabolic processes and oxidative stress. The trace elements are important co-factors in these events. Thus this study was conducted to compare serum levels of lipid profile, Zinc and HbA1c between type 2 diabetic patients and normal controls. The study was designed to find out the relation between lipid profile levels to severity and complication of diabetes mellitus. Degree of lipid profile with antioxidants and blood glucose in Sudanese with type 2 diabetes mellitus. Total 400 human subjects, out of which100 healthy individuals of age group (years) were taken as control and 300 diabetic subjects of age group (years) were taken as cases. There was significant increase in the lipid profile except HDL cholesterol, which is decreased, also significant decrease in trace elements chromium and Zinc. Impaired metabolism of these minerals may have a contributory role in the progression of DM and later development of complications