We describe a case of calciphylaxis in a 54 years old man known Diabetes Type II, Hypertensive and post cadaveric transplant in the year 2000. Patient became hemodialysis dependent after the diagnosis of calciphylaxis was confirmed. Patient was treated with sodium thiosulfate in addition to intensive wound care. The pathology of the calciphylaxis is poorly understood and an effective treatment is not yet well established. Our observation in this case report that sodium thiosulfate failed to show response probably due to the fact that patient has multifactorial risk factors to associate with calciphylaxis before patient deteriorate and passed away four weeks after the diagnosis of calciphylaxis