Adverse drug reactions are an important cause of morbidity and mortality and are responsible for a significant number of hospital admissions ranging from 0.3% to 11%. The ADR reporting rate in India is below 1% compared to worldwide rate of 5%. One of the reasons for low reporting rate in India may be a lack of knowledge and sensitization towards pharmacovigilance and ADR among health care professionals. The aim of the study is to investigate the knowledge, attitudes and perception of health care professionals towards adverse drug reaction reporting. A cross sectional study was carried out using a pretested questionnaire for a period of 6 months among 340 healthcare professionals. The questionnaire was designed to assess the KAP regarding pharmacovigilance. The healthcare professionals (doctors, nurses, dentists and pharmacists), trainee and internship students working in the NMCH and RC, Raichur, Karnataka during the study period were included. About 300 questionnaires where returned which were adequately filled, of which 37% were doctors, 33% dentists, 17% nurses and 13% pharmacists. Mean knowledge score of doctors, dentist, nurses and pharmacists where 5.29±1.73, 4.9±1.13, 5.41±1.34 and 7.08±1.36 respectively. Mean attitude score of doctors, dentist, nurses, pharmacists were 4.87±1.29, 4.78±1.107, 4.53±1.24 and 5.84±1.02 Mean perception score of doctors, dentist, nurses and pharmacists were found to be 4.87±1.29, 4.78±1.107, 4.53±1.24 and 5.84±1.20. It was observed that most of the professionals were aware of ADR. They were having sound knowledge and positive attitude towards ADR reporting. But unfortunately the practice of ADR reporting where deficient among the health care professionals.