The author’s earlier publications have shown the presence of nanoparticles (NPs) of the original drug material in all the higher dilutions of homeopathic drugs; viz, Lycopodium and Ferrummetallicum. The present study is to compare the two different scales of potencies discovered by Samuel Hahnemann; with the help of HRTEM and EDS. It is found that:- i) all the high dilutions (HDs) of Natrummuriaticum (Nat mur) contain NPs; ii) the size of NPs is within quantum dots (QD) size range, except for 6C, where larger particles are found (14nm); iii) NPs contain Sodium (Na) and Chlorine (Cl)in various weight percentages; iv) The smallest NPs in higher concentration are present in 50 millesimal (LM) scale; v) The weight percentage of Na and Cl is very high (more than 99%) in all the potencies of LM scale except in LM6.The combined weight percentage of Na and Cl is less than 1% in all centesimal scale of potencies except in CM, where it is 1.09%; vi) The presence of elements other than Na and Cl is many in centesimal scale. The presence of other elements has been negligible in LM scale and vii) The comparative analysis shows that LM scale HDs are rich in the NPs than in centesimal scale HDs.