A few studies concluded that EASI with oxytocin is a better method of induction than prostaglandin E2 gel whereas a few others observed that EASI efficiency similar to that of prostaglandin compounds. We planned a comparative study of oxytocin and prostaglandin E2 gel in induction of labour in high risk pregnant women from Tamil Nadu from a tertiary care health centre. This study was a prospective study carried out for high risk pregnant women admitted for a medically indicated induction of labor at Rajah Muthiah Medical College and Hospital, Annamalai University. A total of 100 cases were randomly distributed in two groups- 50 cases on cerviprime gel (study group) and 50 cases on oxytocin (control group). Changes in the Bishop scores, labor progress, various labor end points and outcomes of labor were assessed. In Cerviprime (Study group), improved Bishops Score was observed in 2 (4%) study subjects in whom initial Bishops Score was 0 whereas in Oxytocin (Control group), improved Bishops Score was observed in 1 (2%) study subject in whom initial Bishops Score was 0. Cesarean delivery was the outcome of intervention in 8 (16%) study subjects in Cerviprime (Study group) and 20 (40%) participants in Oxytocin (Control group). In both the groups i.e. Cerviprime (Study group) and Oxytocin (Control group), Hyper stimulation and Uterine Inertia were commonly noted Intra-partum complication whereas PPH was most common post-partum complication. Cerviprime can be used as a good tool for induction of labour and as a cervical ripening agent because of its safety to the mother and the foetus. Maternal outcome variables, i.e., induction-labour interval and induction-delivery interval are less in cerviprime as compared to Oxytocin.