In the present investigation, a series of Schiff bases of substituted 4-Amino- 5 –Phenyl-2, 4- dihydro - [1, 2, 4] - triazole -3 –thione were synthesized and evaluated for their anticonvulsant activity and neurotoxicity study. The structures of the synthesized Schiff bases were confirmed by IR, 1H-NMR, and elemental analysis. In anticonvulsant chemo shock method, all the compounds were tested against three chemical stimulants strychnine, thiosemicarbazide and Isonicotinic acid hydrazide (INH) at a dose of 30,100,300 mg/kg at 0.5h to 2hrs time slot and also successfully passed the rotarod test without any sign of neurological defects. The compounds 4A-i, 4A-j, 4A-k, and 4B-i were observed to be most active for anticonvulsant activity while compounds 4A-b, 4A-f, 4A-g, and 4A-h were showing moderate activity. Results indicated that compounds with menthone, camphor derivatives and having chloro-substituted aldehydes/ ketones showed good anticonvulsant activity. Therefore, these derivatives may possible to use as lead compounds for other biological activities also. Overall, the synthesized compounds emerged as more active and less neurotoxic derivatives