1, 3-Thiazine based compounds continue to yield promising antimycobacterial, antibacterial, antipyretic, anti-inflammatory, analgesic, antitumor, and antioxidant agents. The success of these compounds has been based on simple and cost effective synthetic routes and the presence of N-C-S linkage in its scaffold. A number of studies have been reported in the recent years to investigate different biological activities of 1, 3-thiazines. There are different classes of 1, 3-thiazines in the literature which can be divided in to natural and synthetic 1, 3-thiazines. There are several structural classes of synthetic 1, 3-thiazines such as 1, 3-thiazines as dihydro-1, 3-thiazine derivatives, 1, 3-thiazine spiro-derivatives and thioethers; 1, 3-thiazines with heterocyclic rings such as pyrimidine, pyrazole, thiazolidin-4-one and 1, 3, 5-triazine moiety; 1, 3-thiazine-2-amine, amide and hydrazides; 1, 3-thiazines with Schiff’s bases. Herein natural and synthetic 1, 3-thiazine possessing molecules and their therapeutic actions are discussed